ఆక్టా సైకోపాథాలజికా అందరికి ప్రవేశం

నైరూప్య

Antibiomania: a clarithromycin-induced mania?

Rodkin Honjak

The authors report a case of antibiomania in a 55-year-old woman with a history of borderline personality disorder, anorexia nervosa, and chronic anxiety and depressive symptoms associated with her husband's serious illness. The transition to mania followed two 500mg doses of clarithromycin – the third antibiotic she had been administered in four months. Manic symptoms are severe enough to require involuntary hospitalization. The signs of mania disappeared within a week in the psychiatric ward. The authors hypothesize that the pathogenic pathway of this sudden regression may have been triggered by clarithromycin-induced dysmicrobia of the intestinal flora, which entered the CNS through a leaky gut or by direct stimulation of the vagus nerve.