ప్యాంక్రియాస్ జర్నల్ అందరికి ప్రవేశం

నైరూప్య

Survival Analysis of Palliative Surgery of Advanced Stage Periampullary Cancer

Ridho Ardhi Syaiful, Yarman Mazni, Gassani Amalia, Nur Rahadiani, Toar Jean Maurice Lalisang

Context Surgery is the main palliative treatment of advanced periampullary cancer; however, it has high number of post-operative complication, disease recurrence, and mortality. Objective: The objective of the current study was to examine survival rate and prognostic factors of palliative surgery of advanced-stage periampullary cancer.

Methods This was a retrospective cohort study. Patients included in study underwent hepaticojejunostomy and gastrojejunostomy palliative surgery in Cipto Mangunkusumo Hospital. Demographic data, pre-operative laboratory and clinical parameter, cancer spread, histopathological type, and post-operative outcome were collected from medical records from January 2015 until December 2017. One year and 30-day survival rate were analyzed with Kaplan-Meier method. One-year survival comparison, bivariate, and multivariate analysis based on patients’ characteristics was done.

Results One-year survival rate of palliative surgery patients is 19 percent with median (min-max) survival 159 (2-365) days. The 30-day survival rate is 88 percent. Based on variables grouping, hemoglobin (p=0.013) and American Society of Anesthesiologists Classification (ASA classification) (p=0.001) showed significant different of survival estimation statistically.

Conclusions One-year survival rate of palliative surgery of advanced stage periampullary cancer patients was low and associated with hemoglobin value and ASA classification. The 30-day mortality rate of palliative surgery was low, it indicates that palliative surgery is a safe procedure.