Rathinam Prema, Dhana Sekaran Sathish Sekar, Kothapalli Bannoth Chandra Sekhar, Somasundaram Jeevanandham
The paper details a biological investigation on Cissus quadrangularis and Aegle marmelos. The Cytotoxicity of samples on colon: HT-29 cells were determined by the MTT assay .The ethanolic and ethyl acetate crude extract of Cissus quadrangularis and Aegle marmelos have been screened for antitumor potentials using in vitro assay for Cytotoxicity activity (MTT assay) with eight different concentrations. Measurements were performed and the concentration required for a 50% inhibition of viability (IC50) was determined graphically. The effect of the samples on the proliferation of HT-29 was expressed as the % cell viability. From the graphs the concentration of ethanolic and ethyl acetate crude extract yields the value of LC50 (50% mortality) as 62.5μg/ml and 62.5μg/ml respectively for Cissus quadrangularis and Aegle marmelos. In the same way the concentration at which 88% mortality occurs for the ethanolic extract and 83% mortality occurs for the ethyl acetate extract are obtained from the graphs and the values have been found to be 7.8 μg/ml for Cissus quadrangularis and Aegle marmelos respectively.
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