Jim T. Hollande
Cigarette/tobacco smoking may increase your chance of gallstone disease. If this is the case, the reported connections between smoking and pancreatitis may be explained by the fact that smokers have a higher chance of gallstones, which puts them at a higher risk of developing pancreatitis. Smoking causes the exocrine pancreas to undergo pathological and functional alterations, according to a number of experimental studies. Through the signal transduction pathways in pancreatic acinar cells, nicotine causes damage those results in increased intracellular calcium release and/or decreased pancreatic blood flow
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