Sanket Chaniyara, Dron Modi, Ravi Patel, Jay Patel, Rahul Desai, Sunita Chaudhary
Objective: The purpose of this study was to evaluate the potential for oral sustained delivery of ofloxacin. The plasma half-life of ofloxacin was 4 hrs and dose was 200-800mg twice/thrice a day depending on severity of infection. Dose >400mg was given in two divided dose. Hence ofloxacin was chosen as a model drug with an aim to develop a sustained release system for 16 hrs.
Experimental Method: Oral administration of aqueous solution of sodium alginate (1% w/v) containing calcium ion (1.5% w/v) in complexed form resulted in formulation of gel. The effects of different concentration of sodium alginate and calcium carbonate on viscosity and drug release at 10 hrs (% Q10) were studied using 32 factorial designs. The prepared formulation were evaluated for various parameter like floating lag time, total floating time, pH, gelling time and gelling capacity, swelling index, drug content and in-vitro drug release. The optimized formulation was subjected to stability study for 1 month.
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