Nathalia Isabella Muskitta, Natan Kevin Partogu Siagian, Amanda Rumondang
Covid-19 vaccination has proven to be an effective measure to reduce morbidity and mortality. However, some reports have linked Covid-19 vaccination with alterations in menstruation. Considering that menstruation is an important health component for people who menstruate, this information may cause hesitancy to get vaccinated. There are limited systematic reviews regarding the impact of Covid-19 vaccination on changes in menstrual patterns. Therefore, it is necessary to review the available literature on this topic. A systematic review was done in accordance with the PRISMA statement. The literature search was done by hand and on 4 databases: PubMed, EMBASE, ProQuest, and CENTRAL. All found articles were screened based on predetermined criteria. Articles that meet the requirements were critically appraised and analysed. 14 articles consisting of 11 cross-sectional studies and 3 cohorts were found. The outcomes mentioned in the studies include changes in menstrual cycle range, durations, estimated blood quantities, and menstruation symptoms. There are changes in the menstrual pattern after the administration of the Covid-19 vaccination, in the form of irregular menstruation, menorrhagia, worsening of menstruation symptoms, and intermenstrual bleeding. However, these changes only occur temporarily. Therefore, the administration of the Covid-19 vaccination is beneficial for people who menstruate.
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