Rawat Smriti, Bisht Seema & Kothiyal Preeti
This study reports the properties of tableted microparticles based ethylcellulose blend polymers as the controlled release system for diclofenac sodium (DS). Ethylcelulose blend microparticles are prepared through a solvent evaporation process which is a widely used microencapsulation technique in the pharmaceutical industry. The microspheres were characterized for their particle size and distribution, tapped density and encapsulation efficiency. Smaller sized particles with a narrow size distribution were produced with Ethylcellulose .The blend microparticles thus prepared were compressed into tablets using the directly compressible excipients. A cross-sectional view of the tablet reveals the presence of nearly spherical shaped particles in the tablet, suggesting that the system chosen is ideal for tableting. Drug release from compressed tablets was always faster than from uncompressed microspheres, but useful sustained-release characteristics were retained. Dissolution tests of formulations of the tableted microspheres showed increased release rate constants and decreased 50 per cent dissolution times compared to microspheres that had not been compressed. This result indicated that rupture of some of the microspheres had occurred. The drug release rate increased at higher compression pressures due to the rupture of a greater proportion of microspheres. Generally, the least compression pressure that gives tablets with acceptable properties is preferred.
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