రీసెర్చ్ జర్నల్ ఆఫ్ ఆంకాలజీ అందరికి ప్రవేశం

నైరూప్య

Case Report: Alveolar Rhabdomyosarcoma of the Prostate Presenting as Lower Urinary Tract Symptoms in a Young Adult

Tiffany Grace C. Uy

Introduction: Rhabdomyosarcoma (RMS) of the prostate in young adults is exceedingly rare.
Case presentation: A 27 year-old male presented with 2-month history of lower urinary tract symptoms. Prostate was enlarged smooth nontender with no nodularities. PET-CT showed prominent iliac chain lymph nodes, enlarged spleen and multiple osseous lytic and blastic lesions. Histopathology of prostate tissues revealed round cell malignancy, positive for Desmin and myogenin. Archer analysis was positive for PAX3: FOXO1 fusion gene. Patient wasdiagnosed as Alveolar Rhabdomyosarcoma of the prostate Stage IVB (cT4N1M1B-bone). He underwent Vincristine, Dactinomycin and Cyclophosphamide (VAC) chemotherapy.
Conclusion: Prostatomegaly and splenomegaly are unusual findings in a young male. A high index of suspicion will help in detecting prostatic malignancy before it is too late.
Keynote message: This reports the rare case of Alveolar Rhabdomyosarcoma of the prostate in a young male with lower urinary tract symptoms. It highlights the need for high index of suspicion in young patients with prostatomegaly, to help detect malignancy before it is too late.