బయోకెమిస్ట్రీ & మాలిక్యులర్ బయాలజీ జర్నల్ అందరికి ప్రవేశం

నైరూప్య

A Study to find out the Association of Serum Concentrations of Uric Acid and Lipid Profile in Stroke Patients with Diabetes Mellitus

Shrinwanti Karmakar

Background: Stroke is one of the most common causes of death in the developed as well as developing nations. India is also suffering huge social and economic burden in the rehabilitation of stroke patients.

Aims and Objectives: Our present study is to determine serum uric acid and lipid profile level as risk factors of stroke with diabetes mellitus.

Materials and Methods: This is a Cross-sectional observational study conducted in a tertiary care centre, Burdwan Medical College and Hospital, from February 2017 to July 2018. 50 patients of stroke with diabetes mellitus, 50 patients of stroke without diabetes mellitus and 50 patients of diabetes mellitus without stroke were taken according to inclusion and exclusion criteria. Serum Uric acid and Lipid profile were measured by standard biochemical method in all patients. Age, sex distribution and duration of diabetes mellitus are also studied.

Results: Stroke is more common in older population with male predominance. The differences of mean uric acid level in between CVA+DM group (8.172Â ± 1.366 mg/dl) and Only CVA group (6.235Â ± 1.247 mg/dl); & CVA+DM group and Only DM group (5.911Â ± 1.528 mg/dl) are statistically significant (p value <0.05). In Lipid profile there is variable result, the mean difference of TG level, VLDL level and reduced HDL level among the three groups (CVA+DM, Only CVA, Only DM) are statistically significant (p value <0.05). The mean difference of Cholesterol level and LDL level between CVA+DM group and Only CVA group is statistically not significant (p value >0.05) but between CVA+DM group and Only DM group is statistically significant (p value <0.05).

Conclusion: Hyperuricemia is a probable risk factor of stroke, in patients with Diabetes mellitus. Total cholesterol and LDL cholesterol levels are almost similarly elevated in diabetic stroke patients and non-diabetic stroke patients. High Triglyceride, high VLDL and reduced HDL Cholesterol are probable risk factors of stroke in patients with Diabetes mellitus. Chance of developing stroke is more in diabetic patients having greater HbA1C level.